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The reservoir of HIV that is impervious to antiretroviral therapy remains the principal barrier to a cure. Following a cohort of 26 men and 26 women, the researchers, led by Dr. The researchers were tasked with comparing the key differences in latent virus in men and women, and exploring the immune profile, activation levels and distribution of latent viral reservoirs in men versus women. Their first set of findings, detailed in the PNAS paper, lay the groundwork for a preliminary trial to evaluate the effectiveness of the drug tamoxifen combined with the latency-reversing agent vorinostat in reactivating latent HIV in women. It suggests that women may respond differently than men to some curative interventions that are currently under investigation or, perhaps, that an effective cure for women could differ from a cure for men.

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Given their smaller inducible reservoir, would such a strategy be less effective in women? Advertisement Second, since reactivation of the reservoir is inhibited by estrogen, the researchers suggest that "studies of the impact of hormonal contraception on reservoir establishment and its long-term maintenance should be undertaken. This article was originally published by amfAR on Aug. She soon realized, however, that there were very little available data on the topic. So she teamed up with Dr. Rowena Johnston, a co-author of the study. The finding has several important implications. Their first set of findings, detailed in the PNAS paper, lay the groundwork for a preliminary trial to evaluate the effectiveness of the drug tamoxifen combined with the latency-reversing agent vorinostat in reactivating latent HIV in women. Eileen Scully of Massachusetts General Hospital to explore how sex-based differences might affect the HIV reservoir and, by extension, a potential cure. The intent is to shock HIV out of the reservoir so that it can be killed by the immune system or some other killing agent. The reservoir of HIV that is impervious to antiretroviral therapy remains the principal barrier to a cure. Johnston was invited to give a talk on sex differences in HIV cure research at a conference. It suggests that women may respond differently than men to some curative interventions that are currently under investigation or, perhaps, that an effective cure for women could differ from a cure for men. The researchers were tasked with comparing the key differences in latent virus in men and women, and exploring the immune profile, activation levels and distribution of latent viral reservoirs in men versus women. The study concludes that further investigations into sex differences in latency reversal and HIV persistence "are mandatory to extend the benefits of the HIV cure effort to all men and women impacted by the global epidemic. First, one of the main cure strategies being pursued by researchers is "shock and kill" or "kick and kill". We have cross-posted it with their permission. Following a cohort of 26 men and 26 women, the researchers, led by Dr. Jonathan Karn of Case Western Reserve University, found that women have a smaller "inducible" reservoir than men. Mary Heitzeg of the University of Michigan to undertake a systematic review of more than published HIV cure research studies. In other words, while the total size of the reservoir appears to be the same for both sexes, women have a smaller amount of reservoir virus that can be coaxed out of hiding by so-called latency-reversing agents LRAs.

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03.06.2018 at 10:12 pm
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In other words, while the total size of the reservoir appears to be the same for both sexes, women have a smaller amount of reservoir virus that can be coaxed out of hiding by so-called latency-reversing agents LRAs.

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